Selected Publications
Dixit, D., V.M. Hallisey, E.Y.S. Zhu, M. Okuniewska, K. Cadwell, J.E. Chipuk, J.E. Axelrad, S.R. Schwab. S1PR1 inhibition induces pro-apoptotic signaling in T cells and limits humoral responses within lymph nodes. Journal of Clinical Investigation, Vol. 134, e174984, 2024. PMCID: PMC10869180.
Baeyens A., S. Bracero, V.S. Chaluvadi, A. Kholdadadi-Jamayran, M. Cammer, S.R. Schwab. Monocyte-derived S1P in the lymph node regulates immune responses. Nature 2021;592:290-5. PMID:33658712
Okuniewska, M., V. Fang, A. Baeyens, V. Raghavan, J.-Y. Lee, D.R. Littman, S.R. Schwab. SPNS2 enables T cell egress from lymph nodes during an immune response. Cell Reports 2021;36:109368. PMID:34260944
Hammer, G.E., S.R. Schwab, J.C. Sun. Nilabh Shastri: 1952-2021. Nature Immunology 2021;22:533-534. PMID:33782613
Baeyens A., S.R. Schwab. Finding a way out: S1P signaling and immune cell migration. Annual Review of Immunology 2020;28:759-84. PMID:32340572
Dixit, D., M. Okuniewska, S.R. Schwab. Secrets and lyase: Control of sphingosine 1-phosphate distribution. Immunological Reviews 2019;289:173-85. PMID:30977198
Mendoza A., V. Fang, C. Chen, M. Serasinghe, A. Verma, J. Muller, V.S. Chaluvadi, M.L. Dustin, T. Hla, O. Elemento, J.E. Chipuk, S.R. Schwab. Lymphatic endothelial S1P promotes naïve T cell mitochondrial function and survival. Nature 2017;546:158-61. PMID:28538737
Fang V., V.S. Chaluvadi, W.D. Ramos-Perez, A. Mendoza, A. Baeyens, R. Rivera, J. Chun, M. Cammer, S.R. Schwab. Gradients of the signaling lipid S1P in lymph nodes position natural killer cells and regulate their interferon-γ response. Nature Immunology 2017;18:15-25. PMID:27841869
Baeyens, A., V. Fang, C. Chen, S.R. Schwab. Exit Strategies: S1P Signaling and T Cell Migration. Trends in Immunology 2015;36:778-87. PMID:26596799
Ramos-Perez, W.D., V. Fang, D. Escalante-Alcalde, M. Cammer, S.R. Schwab. A map of the distribution of sphingosine 1-phosphate in the spleen. Nature Immunology 2015;16:1245-52. PMID:26502404
Pitt, L. A., A.N. Tikhonova, H. Hu, T. Trimarchi, B. King, Y. Gong, M. Sanchez-Martin, A. Tsirigos, D.R. Littman, A. Ferrando, S.J. Morrison, D.R. Fooksman*, I. Aifantis*, S.R. Schwab*. CXCL12-producing vascular endothelial niches control acute T cell leukemia maintenance. Cancer Cell 2015;27:755-768. PMID:26058075
Mendoza, A., L.A. Pitt, S.R. Schwab. Sphingosine-1-phosphate signaling and lymphocyte trafficking. In “Lysophospholipid Receptors: Signaling and Biochemistry”, edited by Jerold Chun, Timothy Hla, Sarah Spiegel, and Wouter Moolenaar, published by John Wiley & Sons. 2013.
Mendoza, A., B. Breart, W.D. Ramos-Perez, L.A. Pitt, M. Gobert, M. Sunkara, J.J. Lafaille, A.J. Morris, and S.R. Schwab. The transporter Spns2 is required for secretion of lymph but not plasma sphingosine-1-phosphate. Cell Reports 2012; 2:1104-10. PMID:23103166
Breart, B., W.D. Ramos-Perez, A. Mendoza, A.K. Salous, M. Gobert, Y. Huang, R.H. Adams, J.J. Lafaille, D. Escalante-Alcalde, A.J. Morris, S.R. Schwab. Lipid phosphate phosphatase 3 enables efficient thymic egress. Journal of Experimental Medicine 2011;208:1267-78. PMID:21576386